تفاعل #57583

ord-b95a7ebe74064e24a5a8ee037cf564da

معادلة التفاعل

CC(C)S(N)(=O)=O
isopropylsulfonamide
CCOC(=O)c1oc2cccc(OS(=O)(=O)C(F)(F)F)c2c1C
3-methyl-4-trifluoromethanesulfonyloxy-benzofuran-2-carboxylic acid ethyl ester
→
CCOC(=O)c1oc2cccc(NS(=O)(=O)C(C)C)c2c1C
3-methyl-4-(propane-2-sulfonylamino)-benzofuran-2-carboxylic acid ethyl ester
المردود 23.0%

المتفاعلات

CC(C)S(N)(=O)=O
isopropylsulfonamide
CCOC(=O)c1oc2cccc(OS(=O)(=O)C(F)(F)F)c2c1C
3-methyl-4-trifluoromethanesulfonyloxy-benzofuran-2-carboxylic acid ethyl ester

الكواشف

لا شيء

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

Coupling of isopropylsulfonamide with 3-methyl-4-trifluoromethanesulfonyloxy-benzofuran-2-carboxylic acid ethyl ester was carried out according to Example 36, Step 1 to give 3-methyl-4-(propane-2-sulfonylamino)-benzofuran-2-carboxylic acid ethyl ester in 23% yield. 1H NMR (400 MHz, CDCl3) δ ppm 1.4 (t, J=6.4 Hz, 9 H) 2.9 (t, 3 H) 3.5 (m, 1 H) 4.5 (q, J=7.1 Hz, 2 H) 6.6 (s, 1 H) 7.4 (m, 3 H).

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US07420001B2uspto-grants-2008_09