تفاعل #57549

معادلة التفاعل

3-bromobenzonitrile

sulfur

ethylenediamine

→

2-(3-bromo-phenyl)-4,5-dihydro-1H-imidazole

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe mixture was refluxed overnight
2. 2
   workup.ADDITIONthen poured onto ice water, which
3. 3
   أخرىto precipitate as a white solid
4. 4
   أخرىThe product was isolated by vacuum filtration
5. 5
   أخرىdried in a vacuum oven (545 mg, 88%)

الإجراء التجريبي

To a solution of 3-bromobenzonitrile (500 mg, 2.75 mmol) in ethylenediamine (3.5 mL) was added sulfur (44 mg, 1.4 mmol). The mixture was refluxed overnight then poured onto ice water, which caused the product to precipitate as a white solid. The product was isolated by vacuum filtration and dried in a vacuum oven (545 mg, 88%). 1H-NMR (CDCl3) δ 7.93 (t, J=1.7 Hz, 1H), 7.68 (ddd, J=7.8, 1.2, 1.2 Hz, 1H), 7.56 (dddd, J=7.8, 0.9, 0.9, 0.9 Hz, 1H), 7.26 (dd, J=10.5, 8.0 Hz, 1H), 3.78 (br s, 4H).

المصدر