تفاعل #57304

معادلة التفاعل

2-methoxyphenethylamine

thiophosgene

water

→

(2-methoxyphenethyl)isothiocyanate

المردود 71.1%

المذيبات

diethylether

ظروف التفاعل

المعالجة

1. 1
   استخلاصThe mixture was extracted with diethylether (60 ml)
2. 2
   تجفيفdried over anhydrous magnesium sulfate
3. 3
   تركيزconcentrated under reduced pressure

الإجراء التجريبي

To a solution of 2-methoxyphenethylamine (1.98 g) in diethylether (20 ml) was added dropwise under ice-cooling thiophosgene (1.54 g). The mixture was stirred at room temperature for 1 hour. To the solution was added water (30 ml). The mixture was extracted with diethylether (60 ml), dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give (2-methoxyphenethyl)isothiocyanate (1.80 g, yield: 71%) as brown oil.

المصدر