تفاعل #572859

معادلة التفاعل

Trans-(±)-2-amino-5-methyl-4,4a,5,6,7,8,8a,9-octahydrothiazolo[4,5-g]quinoline, dihydrobromide salt

ethanol

ammonium hydroxide

thiourea

→

Trans-(±)-2-amino-5-methyl-4,4a,5,6,7,8,8a,9-octahydrothiazolo[4,5-g]quinoline

المذيبات

chloroform methanol

ظروف التفاعل

المعالجة

1. 1
   أخرىthe product isolated
2. 2
   أخرىwas twice crystallized from methanol
3. 3
   أخرىto yield 0.61 g
4. 4
   أخرىmelting above 235° C
5. 5
   أخرىgave a single spot

الإجراء التجريبي

About 10.8 millimole of the above hydrobromide salt were dissolved in 30 ml. of anhydrous ethanol to which had been added 1.03 g. of thiourea. The reaction was carried out and the product isolated according to the procedure of Example 1. Trans-(±)-2-amino-5-methyl-4,4a,5,6,7,8,8a,9-octahydrothiazolo[4,5-g]quinoline, dihydrobromide salt thus prepared was twice crystallized from methanol to yield 0.61 g. of a colorless crystalline solid melting above 235° C. TLC using 4:1 chloroform-methanol with a trace of aqueous ammonium hydroxide as the solvent system gave a single spot; Rf =0.30.

المصدر