تفاعل #572369

معادلة التفاعل

butanol acetic acid water

1-[N-[(S)-3-(Benzoylamino)-2-oxo-4-phenylbutyl]-L-alanyl]-L-proline, 1,1-dimethylethyl ester

L-proline, monohydrochloride

methanol

→

1-[N-[(S)-3-(Benzoylamino)-2-oxo-4-phenylbutyl]-L-alanyl]-L-proline, monohydrochloride

المذيبات

hydrogen chloride

acetic acid

ظروف التفاعل

المعالجة

1. 1
   تركيزIt is then concentrated
2. 2
   ترشيحfiltered
3. 3
   أخرىto obtain 600 mg

الإجراء التجريبي

1-[N-[(S)-3-(Benzoylamino)-2-oxo-4-phenylbutyl]-L-alanyl]-L-proline, 1,1-dimethylethyl ester (740 mg., 1.46 mmole) is dissolved in a solution of hydrogen chloride in acetic acid (1.5N, 10 ml.) and kept at room temperature for 30 minutes. It is then concentrated, taken into water, filtered and lyophilized to obtain 600 mg. of 1-[N-(S)-3-(benzoylamino)-2-oxo-4-phenylbutyl]-L-alanyl]-L-proline, monohydrochloride; m.p. 83°-163°; [α]D25 =-109° (c=1.04, methanol). Rf 0.6 (silica gel; butanol/acetic acid/water, 4:1:1).

المصدر