تفاعل #57133

معادلة التفاعل

4-[1-ethyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl]aniline

1-pyrrolidinecarbonyl chloride

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title product

المردود 52.0%

N-{4-[1-ethyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl]phenyl}-1-pyrrolidinecarboxamide

المردود 52.0%

المذيبات

pyridine

ظروف التفاعل

المعالجة

1. 1
   تركيزwas then concentrated
2. 2
   أخرىPurification of the residue by Gilson reverse phase HPLC

الإجراء التجريبي

A solution of 4-[1-ethyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl]aniline (0.26 mmol) in pyridine (1 mL) was treated with 1-pyrrolidinecarbonyl chloride (0.29 mmol). The reaction stirred for 18 h at room temperature and was then concentrated. Purification of the residue by Gilson reverse phase HPLC provided the title product as a white powder (52%). ESMS [M+H]+: 401.2

المصدر