تفاعل #57057

معادلة التفاعل

dimethyl methylphosphonate

n-BuLi

Methyl 5-chloropentanoate

→

product

المردود 65.9%

Dimethyl 6-chloro-2-oxohexylphosphonate

المردود 65.9%

المذيبات

THF

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGThe mixture was stirred for 2 hours at −78° C.
2. 2
   أخرىThe mixture was quenched with addition of 1N HCl to pH 4-5
3. 3
   أخرىThe organic layer was separated
4. 4
   غسيلwashed with brine
5. 5
   تجفيفdried over MgSO4
6. 6
   أخرىThe residue was purified through flash chromatography on silica gel (MeOH:CH2Cl2=2:98)

الإجراء التجريبي

To a solution of dimethyl methylphosphonate (2.16 mL, 20 mmol) in anhydrous THF (30 mL), cooled at −78° C. was added n-BuLi (1.6 M in hexane, 13.75 mL, 22 mmol). The mixture was stirred for 30 minutes at this temperature under nitrogen. Methyl 5-chloropentanoate (1.50 g, 10 mmol) was added dropwise for 10 minutes. The mixture was stirred for 2 hours at −78° C., gradually was warm to room temperature. The mixture was quenched with addition of 1N HCl to pH 4-5. The organic layer was separated, washed with brine and dried over MgSO4. The residue was purified through flash chromatography on silica gel (MeOH:CH2Cl2=2:98) to give the product (1.60 g) with colorless oil in 17% yield. 1HNMR (CDCl3, ppm) δ 1.76 (m, 6H), 2.67 (t, J=6.6 Hz, 2H), 3.01 (d, J=21.7 Hz, 2H), 3.35 (t, J=6.2 Hz, 2H), 3.76 (s, 3H), 3.79 (s, 3H).

المصدر