تفاعل #57053

معادلة التفاعل

sodium carbonate

methyl 1-(4-chlorophenyl)cyclobutanecarboxylic acid

sulfuric acid

→

Methyl 1-(4-chlorophenyl)cyclobutanecarboxylate

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe mixture was refluxed for overnight
2. 2
   أخرىThe solvent was evaporated
3. 3
   workup.DISSOLUTIONThe residue was dissolved in ethyl acetate (50 mL)
4. 4
   غسيلwashed with brine (3×10 mL)
5. 5
   تجفيفdried over MgSO4
6. 6
   أخرىThe crude product was used for the next reaction without further purification

الإجراء التجريبي

To a solution of methyl 1-(4-chlorophenyl)cyclobutanecarboxylic acid (5.0 g, 23.73 mmol) in anhydrous methanol was added 1 mL of the concentration of sulfuric acid. The mixture was refluxed for overnight. The mixture was neutralized to pH 4-5 with sodium carbonate. The solvent was evaporated. The residue was dissolved in ethyl acetate (50 mL), washed with brine (3×10 mL), dried over MgSO4. The crude product was used for the next reaction without further purification.

المصدر