تفاعل #5698

معادلة التفاعل

ethyl diethoxyacetate

ammonium hydroxide

→

diethoxyacetamide

المردود 87.0%

المذيبات

CH2Cl2

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المعالجة

1. 1
   أخرىThe ammonia and H2O were evaporated under reduced pressure on a water bath at 50°-60°
2. 2
   أخرىleaving a wet solid
3. 3
   أخرىThe wet solid was dried in a vacuum oven at 53° for 18 hours
4. 4
   أخرىgiving a dark pink solid
5. 5
   ترشيحThe solution was filtered
6. 6
   أخرىto remove a small amount of red insoluble material
7. 7
   تركيزThe filtrate was concentrated
8. 8
   workup.ADDITIONSkellysolve B was added
9. 9
   درجة الحرارةCooling

الإجراء التجريبي

A mixture of 24.85 g of ethyl diethoxyacetate and 140 ml of concentrated ammonium hydroxide was stirred for 3 hours. The ammonia and H2O were evaporated under reduced pressure on a water bath at 50°-60° leaving a wet solid. The wet solid was dried in a vacuum oven at 53° for 18 hours giving a dark pink solid. The solid was dissolved in CH2Cl2. The solution was filtered to remove a small amount of red insoluble material. The filtrate was concentrated and Skellysolve B was added. Cooling gave 18.0 g (87%) of diethoxyacetamide as orange plates, m.p. 76.5-79°.

المصدر