تفاعل #569763

معادلة التفاعل

1-(4-aminobutyl)piperidine

1H-indazole-3-carboxylic acid

1,1'-carbonyldiimidazole

→

oil

المردود 101.3%

N-[4-(1-piperidinyl)butyl]-1H-indazole-3-carboxamide

المردود 101.3%

المذيبات

dimethylformamide

dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGThis solution was then stirred at room temperature for 18 h
2. 2
   أخرىthe volatiles were evaporated
3. 3
   workup.ADDITIONthe residue was diluted with water
4. 4
   استخلاصExtraction with ethyl acetate

الإجراء التجريبي

To a solution of 1H-indazole-3-carboxylic acid (0.745 g, 4.6 mmol) in 20 mL dimethylformamide, was added 1,1'-carbonyldiimidazole (0.745 g, 4.6 mmol). This mixture was stirred at room temperature for 4 h, and to it was added dropwise a solution of 1-(4-aminobutyl)piperidine (0.718 g, 4.6 mmol) dissolved in 3 mL dimethylformamide. This solution was then stirred at room temperature for 18 h, the volatiles were evaporated and the residue was diluted with water. Extraction with ethyl acetate followed by water and brine washes gave 1.40 g of an oil which was sufficiently pure for use in the next reaction. Mass spectrum, m+ =301.

المصدر