تفاعل #56933

معادلة التفاعل

2-(2-amino-6-chloro-pyrimidin-4-yl)-4-bromo-phenol

1-bromomethyl-4-nitro-benzene

cesium carbonate

hydrogen chloride

dioxane

→

6-[5-bromo-2-(4-nitro-benzyloxy)-phenyl]-6-chloro-pyrimidin-2-ylamine

المذيبات

acetonitrile

ethyl acetate

ظروف التفاعل

المعالجة

1. 1
   ترشيحFiltration and concentration of the filtrate
2. 2
   أخرىprovided a crude product which
3. 3
   workup.ADDITIONwas added
4. 4
   ترشيحFiltration

الإجراء التجريبي

A stirred suspension of 2-(2-amino-6-chloro-pyrimidin-4-yl)-4-bromo-phenol (0.151 g, 0.50 mmol), 1-bromomethyl-4-nitro-benzene (0.218 g, 1.0 mmol), and cesium carbonate (0.325 g, 1.0 mmol) in acetonitrile (10 ml) was stirred at 80° C. for 2 hours. Filtration and concentration of the filtrate provided a crude product which was dissolved in ethyl acetate (10 ml) and stirred while a 4 M solution of hydrogen chloride in dioxane (0.50 ml, 2.0 mmol) was added. Filtration provided 6-[5-bromo-2-(4-nitro-benzyloxy)-phenyl]-6-chloro-pyrimidin-2-ylamine as hydrochloride salt (0.23 g, 96% yield).

المصدر