تفاعل #56860

معادلة التفاعل

4-nitro-benzaldehyde

tosylmethyl isocyanide

potassium carbonate

→

5-(4-nitro-phenyl)-oxazole

المردود 89.0%

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas heated
2. 2
   درجة الحرارةunder reflux for 30 minutes
3. 3
   تركيزAfter concentrating under reduced pressure
4. 4
   ترشيحThe solid that was filtered

الإجراء التجريبي

A mixture of 4-nitro-benzaldehyde (5.0 g, 33.1 mmol), tosylmethyl isocyanide (6.4 g, 33.1 mmol) and potassium carbonate (7.8 g, 82.7 mmol) in methanol (100 ml) was heated under reflux for 30 minutes. After concentrating under reduced pressure, the residue was stirred with water (50 ml). The solid that was filtered to afford 5-(4-nitro-phenyl)-oxazole (5.6 g, 89% yield). 1H NMR (acetone-d6) δ 7.89 (s, 1H, Ar), 8.05 (d, 2H, J=9.3 Hz, Ar), 8.35-8.38 (m, 3H, Ar).

المصدر