تفاعل #56845

معادلة التفاعل

4,6-dichloro-pyrimidin-2-yl-amine

sodium acetate

bromine

→

2-amino-4,6-dichloro-5-bromo-pyrimidine

المردود 88.0%

المذيبات

acetic acid

ظروف التفاعل

المعالجة

1. 1
   أخرىVolatiles were evaporated under reduced pressure
2. 2
   workup.STIRRINGThe residue was stirred with water (500 ml) for 1 hour
3. 3
   ترشيحfiltered
4. 4
   أخرىdried under reduced pressure

الإجراء التجريبي

To a stirred mixture of 4,6-dichloro-pyrimidin-2-yl-amine (2.46 g, 15.0 mmol) and sodium acetate (6.15 g, 75.0 mmol) in acetic acid (150 ml) was added bromine (3.24 g, 20.25 mmol) dropwise. The mixture was then stirred at 60° C. for 2 hours. Volatiles were evaporated under reduced pressure. The residue was stirred with water (500 ml) for 1 hour, filtered, and dried under reduced pressure to provide 2-amino-4,6-dichloro-5-bromo-pyrimidine (3.2 g, 88% yield) as a white solid.

المصدر