تفاعل #568138

معادلة التفاعل

4-amino-2-chlorobenzonitrile

trimethylaluminium

methyl 4-[trans-5-[[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]thio]-1,3-dioxan-2-yl]benzoate

→

title compound

المردود 90.0%

3′-Chloro-4′-cyano-4-[trans-5-[[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]thio]-1,3-dioxan-2-yl]benzanilide

المردود 90.0%

ظروف التفاعل

المعالجة

1. 1
   أخرىobtained in Example 12(1)
2. 2
   workup.ADDITIONthe reaction mixture was treated

الإجراء التجريبي

In the same manner as that described in Example 3(4), a reaction was carried out using commercially available 4-amino-2-chlorobenzonitrile (182 mg, 1.2 mmol), trimethylaluminium (1.1 ml, 1.07M n-hexane solution, 1.2 mmol) and methyl 4-[trans-5-[[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]thio]-1,3-dioxan-2-yl]benzoate (150 mg, 0.30 mmol), obtained in Example 12(1), and the reaction mixture was treated using a similar procedure to that described in Example 3(4) to afford the title compound (167 mg, yield 90%) as a colorless oil which was recrystallized from ethyl acetate-isopropyl ether to give white powdery crystals.

المصدر