تفاعل #56809

معادلة التفاعل

sodium carbonate

4,6-dichloro-pyrimidin-2-yl-amine

5-chloro-2-methoxy-phenyl boronic acid

triphenylphosphine

→

4-chloro-6-(5-chloro-2-methoxy-phenyl)-pyrimidin-2-yl-amine

المردود 58.1%

المذيبات

glyme

water

ظروف التفاعل

المعالجة

1. 1
   ترشيحFiltration and concentration of the filtrate
2. 2
   أخرىprovided a residue which
3. 3
   أخرىwas purified by flash chromatography on silica gel eluting with ethyl acetate-hexane (1:3)

الإجراء التجريبي

To a mixture of 4,6-dichloro-pyrimidin-2-yl-amine (0.304 g, 2.0 mmol), 5-chloro-2-methoxy-phenyl boronic acid (0.373 g, 2.0 mmol), palladium (II) acetate (0.068 g, 0.30 mmol) and triphenylphosphine (0.157 g, 0.60 mmol) was added a solution of sodium carbonate (1.36 g, 12.8 mmol) in water (5 ml) followed by glyme (20 ml). The mixture was stirred under an atmosphere of argon for 1 hour. Filtration and concentration of the filtrate provided a residue which was purified by flash chromatography on silica gel eluting with ethyl acetate-hexane (1:3) to provide 4-chloro-6-(5-chloro-2-methoxy-phenyl)-pyrimidin-2-yl-amine (0.314 g, 58% yield) as a white powder.

المصدر