تفاعل #56803

معادلة التفاعل

(S)-Epichlorohydrin

piperazine sulfonamide

ethanol

→

title intermediate

1-chloro-(S)-2-hydroxy-3-(4-methanesulfonylpiperazin-1-yl)propane

ظروف التفاعل

المعالجة

1. 1
   أخرىthe white solid precipitate which formed
2. 2
   ترشيحwas collected by filtration
3. 3
   غسيلwashed with ethanol

الإجراء التجريبي

(S)-Epichlorohydrin (48.0 mL, 0.612 mol) was added to a stirred solution of piperazine sulfonamide (87.3 g, 0.532 mol) in ethanol (1.33 L) at room temperature. The reaction mixture was stirred for 18 h and the white solid precipitate which formed was collected by filtration and washed with ethanol to afford the title intermediate (107.76 g) as a white solid which was used without further purification. (m/z): [M+H]+ calcd for C8H17ClN2O3S, 257.07; found 257.2. 1H NMR (DMSO-d6): δ (ppm) 2.37 (dd, 1H), 2.45 (dd, 1H), 2.50-2.58 (m, 4H), 2.86 (s, 3H), 3.09 (m, 4H), 3.55 (dd, 1H), 3.65 (dd, 1H), 3.84 (m, 1H), 5.09 (d, 1H).

المصدر