تفاعل #56797

معادلة التفاعل

CF3CO2H

(Boc)2O

CH3S(O)2Cl

3-(methylamino)-1-benzylpyrrolidine

i-Pr2NEt

→

3-(Methylamino)-1-(methanesulfonyl)pyrrolidine

المذيبات

CH2Cl2

MeOH

EtOH

CH2Cl2

ظروف التفاعل

الإجراء التجريبي

3-(Methylamino)-1-(methanesulfonyl)pyrrolidine was prepared from 3-(methylamino)-1-benzylpyrrolidine after four steps: i) (Boc)2O, MeOH, rt; ii) H2 (1 atm), 10% Pd/C, EtOH; iii) CH3S(O)2Cl, i-Pr2NEt, CH2Cl2; iv) CF3CO2H, CH2Cl2. (m/z): [M+H]+ calcd for C6H14N2O2S: 179.08; found, 179.2. 3R-Methylamino-1-(methanesulfonyl)pyrrolidine was prepared in a similar manner from (3R)-(methylamino)-1-benzylpyrrolidine.

المصدر