تفاعل #56795

معادلة التفاعل

1,3-acetonedicarboxylic acid

aminotropane

2,5-dimethoxy tetrahydrofuran

→

8-benzyl-8-azabicyclo[3.2.1]octan-3-one

ظروف التفاعل

الإجراء التجريبي

For example, the protected aminotropane intermediate 16 can be prepared by reacting 2,5-dimethoxy tetrahydrofuran 17 with 1,3-acetonedicarboxylic acid 18 to provide 8-benzyl-8-azabicyclo[3.2.1]octan-3-one 19, commonly N-benzyltropanone. N-benzyltropanone is then reacted with a slight excess of di-tert-butyl dicarbonate in the presence of a transition metal catalyst to provide the protected Boc intermediate 20, which is reduced to provide the protected aminotropane intermediate 16.

المصدر