تفاعل #5675

معادلة التفاعل

5-dimethylamino-2,3,4,5-tetrahydro-1H-benzazepine

potassium carbonate

p-nitrobenzoyl chloride

→

5-dimethylamino-1-(4-nitrobenzoyl)-2,3,4,5-tetrahydro-1H-benzazepine

المردود 97.1%

المذيبات

water

acetone

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةcooling
2. 2
   workup.STIRRINGthe mixture is stirred at room temperature overnight
3. 3
   ترشيحthe precipitated crystals are collected by filtration
4. 4
   أخرىdried

الإجراء التجريبي

To a solution of 5-dimethylamino-2,3,4,5-tetrahydro-1H-benzazepine (50 g) in a mixture of acetone (400 ml) and water (200 ml) is added potassium carbonate (38.8 g), and thereto is added p-nitrobenzoyl chloride (40 g) with stirring under ice-cooling, and the mixture is stirred at room temperature overnight. To the reaction mixture is added an appropriate amount of water, and the precipitated crystals are collected by filtration and dried to give 5-dimethylamino-1-(4-nitrobenzoyl)-2,3,4,5-tetrahydro-1H-benzazepine (71 g) as pale yellow powder, mp. 139°-142° C.

المصدر