تفاعل #56720

معادلة التفاعل

THF

ethyl cyanoacetate

1-methylcyclopropane-methanol

PCC

→

ester

المردود 26.2%

2-Cyano-3-(1-methyl-cyclopropyl)-acrylic acid ethyl ester

المردود 26.2%

المذيبات

CH2Cl2

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe mixture was filtered through a 1 cm plug of silica gel under vacuum
2. 2
   غسيلrinsed with Et2O
3. 3
   تركيزThe filtrate was concentrated to ca. 5 mL total volume
4. 4
   أخرىpartitioned between Et2O and sat. aq. NaHCO3
5. 5
   أخرىThe phases were separated
6. 6
   غسيلthe organic phase washed with brine
7. 7
   تجفيفdried (MgSO4)
8. 8
   تركيزconcentrated

الإجراء التجريبي

To 1-methylcyclopropane-methanol (Aldrich, 1.13 mL, 11.6 mmol) in 50 mL CH2Cl2 was added neutral alumina (2.5 g) and then PCC (2.5 g, 11.6 mmol), and the mixture stirred 3 h at ambient temperature. The mixture was filtered through a 1 cm plug of silica gel under vacuum, and rinsed with Et2O. The filtrate was concentrated to ca. 5 mL total volume. To the residue was added THF (10 mL), ethyl cyanoacetate (1.2 mL, 11.3 mmol), piperidine (5 drops), and finally acetic acid (5 drops). The whole was stirred at ambient temperature overnight, then partitioned between Et2O and sat. aq. NaHCO3. The phases were separated and the organic phase washed with brine, dried (MgSO4), and concentrated. Flash chromatography of the residue (10→15% EtOAc/hexanes) provided 0.53 g (25%) of the ester as a colorless oil that crystallized on standing. Anal. Calcd for C10H13NO2: C, 67.02; H, 7.31; N, 7.82. Found: C, 66.86; H, 7.47; N, 7.70.

المصدر