تفاعل #56668

معادلة التفاعل

water

trans-ethyl 4-(4-aminocyclohexyl)benzoate

triethylamine

benzyl chloroformate

→

trans-Ethyl 4-(4-(N-benzyloxycarbonylamino)cyclohexyl)benzoate

المذيبات

dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   استخلاصextracted with ethyl acetate
2. 2
   أخرىdried
3. 3
   أخرىthe solvent is evaporated off
4. 4
   أخرىThe residue is purified by chromatography on a silica gel column
5. 5
   غسيلeluting with an 8/2 cyclohexane/ethyl acetate mixture
6. 6
   أخرىThe compound of the title is obtained

الإجراء التجريبي

A mixture of 2.0 g (0.0008 mol) of trans-ethyl 4-(4-aminocyclohexyl)benzoate, 1.25 ml of triethylamine and 1.26 ml (0.0084 mol) of benzyl chloroformate at 95% in 40 ml of dimethylformamide is stirred at room temperature for 3 hours. The mixture is poured into water, extracted with ethyl acetate and dried, and the solvent is evaporated off. The residue is purified by chromatography on a silica gel column, eluting with an 8/2 cyclohexane/ethyl acetate mixture. The compound of the title is obtained.

المصدر