تفاعل #566659

معادلة التفاعل

NaOH

Racemic tert-butylglycine

NaOH

HCl

o-toluoyl chloride

→

desired product

المردود 57.6%

3,3-dimethyl-2-((2-methylbenzoyl)amino)butanoic acid

المردود 57.6%

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe mixture was warmed to ambient temperature
2. 2
   أخرىrecooled to 5° C.
3. 3
   أخرىThe thick precipitate that formed
4. 4
   ترشيحwas collected by filtration
5. 5
   غسيلwashed with cold water

الإجراء التجريبي

Racemic tert-butylglycine (502 mg, 3.83 mmol) was dissolved in water (10 mL) containing NaOH (153 mg, 3.83 mmol). This solution was cooled to 5° C. and treated with o-toluoyl chloride (0.501 mL, 3.83 mmol) followed by additional NaOH (153 mg, 3.83 mmol). The mixture was warmed to ambient temperature, stirred for 1.5 hours, recooled to 5° C., and treated with 1M HCl (pH 3). The thick precipitate that formed was collected by filtration and washed with cold water to provide 550 mg of the desired product as a white solid.

المصدر