تفاعل #56591

معادلة التفاعل

sodium bicarbonate

ether

dihydropyrane

6-chlorohexanol

→

product

المردود 86.6%

2-(6-Chlorohexyloxy)tetrahydropyrane

المردود 86.6%

المذيبات

methylenechloride

methylenechloride

ظروف التفاعل

المعالجة

1. 1
   غسيلThe ether phase was washed with water
2. 2
   تجفيفdried over sodium sulphate
3. 3
   ترشيحfiltered
4. 4
   تركيزconcentrated to dryness

الإجراء التجريبي

To a mixture of 15 g of 6-chlorohexanol, 100 ml of methylenechloride and 0.2 g of p-toluenesulphonic acid were added dropwise 12 g of dihydropyrane in 40 ml of methylenechloride. The reaction mixture was stirred for 15 h at room temperature and then distributed between ether and saturated sodium bicarbonate solution. The ether phase was washed with water, dried over sodium sulphate, filtered and concentrated to dryness. Chromatography of the residue on silica using hexane/ether (3:1) gave 21 g of the product as a colourless oil.

المصدر