تفاعل #56590

معادلة التفاعل

2-(6-chlorohexyloxy)tetrahydropyrane

hydroquinone

potassiumcarbonate

potassiumiodide

→

product

المردود 82.5%

4-(6-(2-Tetrahydropyranyl)oxyhexyloxy)phenol

المردود 82.5%

المذيبات

dimethylsulfoxide

water

ظروف التفاعل

المعالجة

1. 1
   أخرىto react for 4 days at 80° C
2. 2
   استخلاصextracted with ether
3. 3
   تجفيفThe organic phase was then dried over sodium sulphate
4. 4
   ترشيحfiltered
5. 5
   تركيزconcentrated to dryness

الإجراء التجريبي

A mixture of 10 g of 2-(6-chlorohexyloxy)tetrahydropyrane, 25 g of hydroquinone, 31 g of potassiumcarbonate, 0.752 g of potassiumiodide and 250 ml of dimethylsulfoxide was allowed to react for 4 days at 80° C. Subsequently, the reaction mixture was cooled to room temperature and after addition of water extracted with ether. The organic phase was then dried over sodium sulphate, filtered and concentrated to dryness. Chromatography on silica with 10% ethylacetate in toluene gave 11 g of product as a yellowish oil.

المصدر