تفاعل #56579

معادلة التفاعل

1,3-dicyclohexylcarbodiimide

1-(z,z,z-octadeca-6,9,12-trienoyloxy)-3-hydroxypropane

z-octadeca-9-enoic acid

→

1-(z,z,z-octadeca-6,9,12-trienoyloxy)-3-(z-octadeca-9-enoyloxy)propane

المذيبات

hexane

methylene chloride

methylene chloride

ظروف التفاعل

المعالجة

1. 1
   أخرىOn completion of reaction
2. 2
   ترشيحfiltered
3. 3
   تركيزconcentrated
4. 4
   أخرىpurified
5. 5
   أخرىby dry column chromatography

الإجراء التجريبي

A solution of 1,3-dicyclohexylcarbodiimide (23.7 g) and 4-(N,N-dimethylamino)pyridine (15.9 g) in methylene chloride (200 ml) was added to a solution of 1-(z,z,z-octadeca-6,9,12-trienoyloxy)-3-hydroxypropane (33.6 g) and z-octadeca-9-enoic acid (30 g) in methylene chloride (400 ml) under nitrogen at room temperature. On completion of reaction as evidenced by tic analysis the solution was diluted with hexane, filtered, concentrated and purified by dry column chromatography to yield 1-(z,z,z-octadeca-6,9,12-trienoyloxy)-3-(z-octadeca-9-enoyloxy)propane as a free flowing pale yellow oil.

المصدر