تفاعل #56561

معادلة التفاعل

ethyl 2-(2-formylaminothiazol-4-yl)glyoxylate

ethyl 2-(2-formylimino-2,3-dihydrothiazol-4-yl)glyoxylate

sodium hydroxide

→

2-(2-formylaminothiazol-4-yl)glyoxylic acid

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةice-cooling
2. 2
   workup.STIRRINGthe mixture was stirred for 5 minutes at 10° to 15° C
3. 3
   ترشيحAfter the reaction mixture was filtered
4. 4
   workup.STIRRINGwith stirring
5. 5
   ترشيحThe precipitates were collected by filtration
6. 6
   غسيلwashed with water
7. 7
   أخرىdried

الإجراء التجريبي

To a suspension of ethyl 2-(2-formylaminothiazol-4-yl)glyoxylate, which can be represented as ethyl 2-(2-formylimino-2,3-dihydrothiazol-4-yl)glyoxylate, (281 g.) in water (1100 ml.) was added an 1 N sodium hydroxide aqueous solution (2.23 l.) under stirring and ice-cooling, and then the mixture was stirred for 5 minutes at 10° to 15° C. After the reaction mixture was filtered, the filtrate was adjusted to pH 1 with concentrated hydrochloric acid with stirring. The precipitates were collected by filtration, washed with water and then dried to give 2-(2-formylaminothiazol-4-yl)glyoxylic acid, which can be represented as 2-(2-formylimino-2,3-dihydrothiazol-4-yl)glyoxylic acid, (234 g.), mp 133° to 136° C. (dec.).

المصدر