تفاعل #565489

معادلة التفاعل

3-Amino-2-cyclopenten-1-one

3-bromo-4-fluorobenzaldehyde

product

2,2-dimethyl-2H-pyran-3,5(4H,6H)-dione

→

title compound

المردود 54.2%

5-(3-bromo-4-fluorophenyl)-3,3-dimethyl-5,7,8,9-tetrahydrocyclopenta[b]pyrano[4,3-e]pyridine-4,6(1H,3H)-dione

المردود 54.2%

ظروف التفاعل

الإجراء التجريبي

3-Amino-2-cyclopenten-1-one (Kikani, B. B., Synthesis, (1991), 2,176) (0.099 g, 1.0 mmol), 3-bromo-4-fluorobenzaldehyde (0.21 g, 1.0 mmol) and the product from Example 66C (0.15 g, 1.0 mmol) were processed as described in Example 31 to provide the title compound (0.22 g).

المصدر