تفاعل #56542

معادلة التفاعل

2-cyano-2-(2-chlorophenyl)-2-(4-chlorophenyl)ethanol

methane sulfonyl chloride

triethylamine

→

2-cyano-2-(2-chlorophenyl)-2-(4-chlorophenyl)ethyl methane sulfonate

المذيبات

benzene

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةheated on a steam bath for another 30 minutes
2. 2
   أخرىThe precipitate formed
3. 3
   ترشيحis filtered
4. 4
   غسيلthe filtrate is washed with dilute hydrochloric acid, water, saturated sodium bicarbonate solution, saturated sodium chloride solution
5. 5
   تجفيفdried over magnesium sulfate
6. 6
   أخرىThe solvent is evaporated
7. 7
   أخرىto give 22 g

الإجراء التجريبي

To a mixture of 2-cyano-2-(2-chlorophenyl)-2-(4-chlorophenyl)ethanol (18 g., 0.06 mole) and methane sulfonyl chloride (7.8 g., 0.07 mole) in 200 ml. of benzene is added dropwise at 10° C., 7.5 g. (0.08 mole) of triethylamine. The reaction mixture is stirred at room temperature for 30 minutes and then heated on a steam bath for another 30 minutes. The precipitate formed is filtered and the filtrate is washed with dilute hydrochloric acid, water, saturated sodium bicarbonate solution, saturated sodium chloride solution and dried over magnesium sulfate. The solvent is evaporated to give 22 g. of product; mp 124°-7° C., which is identified by nmr.

المصدر