تفاعل #56536

معادلة التفاعل

α-n-octyl-2,4-dichlorobenzyl cyanide

pyridine

paraformaldehyde

benzyl triethylammonium hydroxide

→

2-cyano-2-(2,4-dichlorophenyl)decan-1-ol

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONis added 1 ml
2. 2
   استخلاصextracted with ether
3. 3
   غسيلThe combined ether extracts are washed with water, saturated sodium chloride solution
4. 4
   تجفيفdried over magnesium sulfate
5. 5
   أخرىThe solvent is evaporated
6. 6
   أخرىto give 40 g

الإجراء التجريبي

To an ice cold stirred solution of α-n-octyl-2,4-dichlorobenzyl cyanide (40 g., 0.14 mole) in 250 ml. of pyridine containing a suspension of paraformaldehyde (21 g., 0.7 mole) is added 1 ml. of benzyl triethylammonium hydroxide. The mixture is stirred under nitrogen at room temperature for 72 hours. The reaction mixture is poured into 2 liters of water and extracted with ether. The combined ether extracts are washed with water, saturated sodium chloride solution and dried over magnesium sulfate. The solvent is evaporated to give 40 g. of a thick oil.

المصدر