تفاعل #564158

معادلة التفاعل

2,2-difluoro-4-methyl-1,3-benzodioxole

Azobisisobutyronitrile

N-bromosuccinimide

→

4-Bromomethyl-2,2-difluoro-1,3-benzodioxole

المذيبات

methylene chloride

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe mixture is then heated
2. 2
   درجة الحرارةunder reflux
3. 3
   درجة الحرارةAfter cooling
4. 4
   ترشيحthe succinimide is filtered off with suction
5. 5
   غسيلrinsed with carbon tetrachloride
6. 6
   workup.DISTILLATIONthe solution is then distilled in order
7. 7
   أخرىto separate off the carbon tetrachloride
8. 8
   أخرىare employed without purification

الإجراء التجريبي

76 g of 2,2-difluoro-4-methyl-1,3-benzodioxole and 200 mg of Azobisisobutyronitrile are added to a suspension of 90 g of N-bromosuccinimide in 400 ml of methylene chloride. The mixture is then heated under reflux, with stirring, until all the undissolved material floats to the top. After cooling, the succinimide is filtered off with suction and rinsed with carbon tetrachloride and the solution is then distilled in order to separate off the carbon tetrachloride. 117 g of crude benzyl bromide remain in the residue and are employed without purification.

المصدر