تفاعل #564152

معادلة التفاعل

2,2-difluoro-1,3-benzodioxole

methyl acetoacetate

acetic anhydride

→

Methyl (2,2-difluoro-1,3-benzodioxol-5-yl)-methyleneacetoacetate

ظروف التفاعل

المعالجة

1. 1
   workup.WAITafter brief warming, the mixture is left
2. 2
   أخرىhydrolyzed with 1 l of ice-water and the oil which has separated out
3. 3
   أخرىis separated off
4. 4
   workup.ADDITIONdiluted with a little methylene chloride
5. 5
   أخرىdried

الإجراء التجريبي

50 mmol of 5-butyliminomethyl)-2,2-difluoro-1,3-benzodioxole and 50 mmol of methyl acetoacetate are added simultaneously to 80 ml of acetic anhydride and, after brief warming, the mixture is left to stand at room temperature for 24 hours. It is then hydrolyzed with 1 l of ice-water and the oil which has separated out is separated off, diluted with a little methylene chloride, dried and subsequently used as the crude product.

المصدر