تفاعل #564018

معادلة التفاعل

N,N-dimethylacetamide

5-amino-2-mercaptobenzimidazole

phenyl chloroformate

→

2-mercapto-5-phenoxycarbonylaminobenzimidazole

المردود 76.1%

المذيبات

pyridine

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwas added dropwise at room temperature
2. 2
   أخرىAs a result, crystals precipitated
3. 3
   ترشيحThe resulting crystals were collected by filtration
4. 4
   أخرىrecrystallized from acetonitrile

الإجراء التجريبي

N,N-dimethylacetamide (250 ml) was added to 36.6 g of 5-amino-2-mercaptobenzimidazole and 17.1 ml of pyridine, and 34.4 g of phenyl chloroformate was added dropwise at room temperature. The mixture was stirred at room temperature for 1.5 hours, and 1.5 liters of ice water was added. As a result, crystals precipitated. The resulting crystals were collected by filtration and recrystallized from acetonitrile to give 47.7 g of 2-mercapto-5-phenoxycarbonylaminobenzimidazole.

المصدر