تفاعل #563530

معادلة التفاعل

1,18-octadecanedioic acid mono benzyl ester

N-hydroxysuccinimide

→

benzyl 18-[(2,5-dioxo-1-pyrrolidinyl)oxy]-18-oxooctadecanoate

المذيبات

NMP

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe reaction mixture was cooled to 25° C.
2. 2
   أخرىthe precipitate was removed by filtration
3. 3
   غسيلwashed with water (4.7 L)

الإجراء التجريبي

1,18-octadecanedioic acid mono benzyl ester (120 g, 0.3 mol), N-hydroxysuccinimide (41 g, 0.36 mol) and N,N-dicyclohexylcarbodiimide (74 g, 0.36 mol) were dissolved in NMP (1200 ml) and heated to 60° C. for 2.5 hr. The reaction mixture was cooled to 25° C. and the precipitate was removed by filtration and washed with water (4.7 L). The crude precipitate was recystallised from 2-propanol (1250 ml), affording benzyl 18-[(2,5-dioxo-1-pyrrolidinyl)oxy]-18-oxooctadecanoate. Yield 138 g (92%).

المصدر