تفاعل #56293

معادلة التفاعل

7β-phenylacetamido-3-[2-(N-carboethoxysulfamoyl)benzoyloxy]methyl-3-cephem-4-carboxylic acid

5-mercapto-1-methyl-1H-tetrazole

phosphoric acid

sodium hydrogen carbonate

→

7β-phenylacetamido-3-(1-methyl-1H-tetrazol-5-yl) thiomethyl-3-cephem-4-carboxylic acid

المردود 81.1%

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   استخلاصextracted with ethyl acetate (100 ml)
2. 2
   غسيلThe extract is rinsed with a saturated aqueous solution of sodium chloride
3. 3
   أخرىdried
4. 4
   تركيزconcentrated
5. 5
   workup.ADDITIONthe addition of ether
6. 6
   ترشيحthe precipitate is recovered by filtration

الإجراء التجريبي

In water (50 ml) is suspended 7β-phenylacetamido-3-[2-(N-carboethoxysulfamoyl)benzoyloxy]methyl-3-cephem-4-carboxylic acid (3.0 g) together with 5-mercapto-1-methyl-1H-tetrazole (1.0 g). The mixture is adjusted to pH 5.5 with sodium hydrogen carbonate and the resultant solution is heated at 60° C. for 50 minutes. The solution is brought to pH 2.0 with dilute phosphoric acid and extracted with ethyl acetate (100 ml). The extract is rinsed with a saturated aqueous solution of sodium chloride, dried and concentrated. Then, following the addition of ether, the precipitate is recovered by filtration. By the above procedure is obtained 7β-phenylacetamido-3-(1-methyl-1H-tetrazol-5-yl) thiomethyl-3-cephem-4-carboxylic acid (1.8 g).

المصدر