تفاعل #56255

معادلة التفاعل

adenosine-5'-carboxylic acid methyl ester

n-butanol

→

crude product

المردود 87.0%

Adenosine-5'-carboxylic acid n-butyl ester

المردود 87.0%

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةunder reflux for 3 hours
2. 2
   ترشيحThe reaction mixture is filtered
3. 3
   أخرىthe filtrate evaporated in a vacuum
4. 4
   أخرىThe evaporation residue is triturated with ether
5. 5
   ترشيحfiltered off with suction
6. 6
   غسيلagain washed with ether
7. 7
   أخرىdried

الإجراء التجريبي

5 g of adenosine-5'-carboxylic acid methyl ester are dissolved in 200 ml of n-butanol and, together with 3 g of D-benzedrine, boiled under reflux for 3 hours. The reaction mixture is filtered and the filtrate evaporated in a vacuum. The evaporation residue is triturated with ether, filtered off with suction, again washed with ether and dried. There are thus obtained 5.6 g of adenosine-5'-carboxylic acid n-butyl ester, which has a melting point of 166°-167° C. The yield is 87% of theory. The crude product obtained can be recrystallized from water.

المصدر