تفاعل #562452

معادلة التفاعل

4-amino-2-chlorobenzonitrile

N-iodosuccinimide

→

4-amino-2-chloro-5-iodobenzonitrile

المردود 39.2%

المذيبات

HOAc

ظروف التفاعل

المعالجة

1. 1
   أخرىA brown solid formed
2. 2
   ترشيحwhich was collected by filtration
3. 3
   غسيلwashed with hexanes
4. 4
   أخرىdried in vacuo

الإجراء التجريبي

A mixture of 4-amino-2-chlorobenzonitrile (5.0 g, 0.033 mol) and N-iodosuccinimide (8.28 g, 0.036 mol) in HOAc (35 mL) was stirred at RT overnight. A brown solid formed, which was collected by filtration, washed with hexanes, and dried in vacuo to afford 3.6 g (39%) of 4-amino-2-chloro-5-iodobenzonitrile (236) as a pale brown solid: MS (ESI) m/z=278.8 [M+1]+.

المصدر