تفاعل #5619

معادلة التفاعل

1-methyl-4-(4-hydroxy-5-benzyloxy-2-pyridylcarbonyl)piperazine

→

1-methyl-4-(4,5-dihydroxy-2-pyridylcarbonyl)piperazine

المردود 38.7%

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   أخرىAfter the catalyst was removed by filtration
2. 2
   أخرىthe filtrate was evaporated to dryness

الإجراء التجريبي

To a solution of 1-methyl-4-(4-hydroxy-5-benzyloxy-2-pyridylcarbonyl)piperazine (4.71 g) in methanol (300 ml) was added 10 palladium-carbon (2.35 g) in a stream of nitrogen and the mixture was hydrogenated at atmospheric pressure for 20 minutes. After the catalyst was removed by filtration, the filtrate was evaporated to dryness. The residue was recyrstallized from methanol to give 1-methyl-4-(4,5-dihydroxy-2-pyridylcarbonyl)piperazine (1.32 g).

المصدر