تفاعل #56159

معادلة التفاعل

2,6-dichloro-4-phenyl-3-cyano-pyridine

morpholine

→

2-chloro-6-morpholino-4-phenyl-3-cyano-pyridine

المردود 86.1%

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe resulting mixture was refluxed for about two hours
2. 2
   درجة الحرارةEven while refluxing
3. 3
   درجة الحرارةprimarily upon subsequent cooling (optionally on an ice water bath) of the reaction mixture
4. 4
   أخرىa colorless crystalline precipitate formed which
5. 5
   ترشيحwas collected by suction filtration
6. 6
   غسيلvery thoroughly washed with water
7. 7
   أخرىdried

الإجراء التجريبي

A suspension of 24.9 gm (0.1 mol) of 2,6-dichloro-4-phenyl-3-cyano-pyridine in 400 ml of ethanol was slowly admixed with 17.4 gm (0.2 mol) of morpholine, and the resulting mixture was refluxed for about two hours. Even while refluxing, but primarily upon subsequent cooling (optionally on an ice water bath) of the reaction mixture, a colorless crystalline precipitate formed which was collected by suction filtration, very thoroughly washed with water and dried. 25.8 gm (86% of theory) of 2-chloro-6-morpholino-4-phenyl-3-cyano-pyridine, m.p. 198°-200° C., were obtained.

المصدر