تفاعل #5614

معادلة التفاعل

5-benzyloxy-2-hydroxymethyl-4-pyridone

thionyl chloride

→

5-benzyloxy-2-chloromethyl-4-pyridone

المذيبات

benzene

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGAfter being stirred at the same temperature for 30 minutes
2. 2
   درجة الحرارةthe mixture was refluxed for 4 hours
3. 3
   ترشيحThe precipitate was collected by filtration
4. 4
   غسيلwashed with benzene
5. 5
   أخرىdried under reduced pressure

الإجراء التجريبي

To a suspension of 5-benzyloxy-2-hydroxymethyl-4-pyridone (33 g) in benzene (500 ml) was added thionyl chloride (28.4 ml) at ambient temperature under stirring. After being stirred at the same temperature for 30 minutes, the mixture was refluxed for 4 hours. The resulting mixture was cooled to ambient temperature. The precipitate was collected by filtration, washed with benzene and dried under reduced pressure to give 5-benzyloxy-2-chloromethyl-4-pyridone (41.5 g).

المصدر