تفاعل #5610

معادلة التفاعل

5-benzyloxy-2-vinyl-4-pyridone

pyrrolidine

→

5-benzyloxy-2-[2-(1-pyrrolidinyl)ethyl]4-pyridone

المذيبات

tetrahydrofuran

diisopropyl ether

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas heated
2. 2
   درجة الحرارةrefluxed for an hour
3. 3
   درجة الحرارةThe mixture was cooled
4. 4
   ترشيحthe resulting precipitate was collected by filtration
5. 5
   غسيلwashed with diisopropyl ether
6. 6
   أخرىair-dried at ambient temperature

الإجراء التجريبي

A mixture of 5-benzyloxy-2-vinyl-4-pyridone (2.90 g) and pyrrolidine (5.33 ml) was heated and refluxed for an hour. The mixture was cooled and diluted with tetrahydrofuran (20 ml) and diisopropyl ether (80 ml). After being stirred for an hour at ambient temperature, the resulting precipitate was collected by filtration, washed with diisopropyl ether and air-dried at ambient temperature to give 5-benzyloxy-2-[2-(1-pyrrolidinyl)ethyl]4-pyridone (3.79 g).

المصدر