تفاعل #56085

معادلة التفاعل

benzyl 2-p-isobutylphenylpropionate

aluminum chloride

→

2-p-isobutylphenylpropionic acid

المردود 91.0%

المذيبات

ethyl acetate

methylene chloride

nitromethane

anisole

ظروف التفاعل

المعالجة

1. 1
   غسيلwashed with hydrochloric acid and water
2. 2
   أخرىdried
3. 3
   أخرىevaporated
4. 4
   أخرىThe residue is recrystallized with n-hexane

الإجراء التجريبي

To a solution of benzyl 2-p-isobutylphenylpropionate (3 g) in methylene chloride (18 ml) are added a solution of aluminum chloride (4 g) in nitromethane (50 ml) and anisole (3 ml) at 0° C., and the mixture is stirred at room temperature for 6 hours. The reaction mixture is diluted with ethyl acetate, washed with hydrochloric acid and water, dried and evaporated. The residue is recrystallized with n-hexane to give 2-p-isobutylphenylpropionic acid (186 mg) melting at 75°-77.5° C. Yield 91%.

المصدر