تفاعل #5608

معادلة التفاعل

2-chloromethyl-5-benzyloxy-4-pyridone

tetrahydrofuran

dimethylamine hydrochloride

sodium hydroxide

→

5-benzyloxy-2-(N,N-dimethylamino)methyl-4-pyridone

المردود 96.7%

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   تركيزthe mixture was concentrated under reduced pressure to dryness
2. 2
   workup.DISSOLUTIONThe residue was dissolved in methanol
3. 3
   ترشيحthe insoluble material was filtered off
4. 4
   أخرىThe filtrate was evaporated in vacuo

الإجراء التجريبي

To a mixture of 2-chloromethyl-5-benzyloxy-4-pyridone (1.0 g), tetrahydrofuran (10 ml) and water (10 ml) were added dimethylamine hydrochloride (1.31 g) and sodium hydroxide (0.64 g). After being stirred for 1.5 hours, the mixture was concentrated under reduced pressure to dryness. The residue was dissolved in methanol and the insoluble material was filtered off. The filtrate was evaporated in vacuo to give 5-benzyloxy-2-(N,N-dimethylamino)methyl-4-pyridone (1.0 g) as a powder.

المصدر