تفاعل #56040

معادلة التفاعل

water

2-chloro-5-cyano-6-methyl-3-pyridine-carboxylic acid, ethyl ester

sec. butylamine

→

5-Cyano-6-methyl-2-[(1-methylpropyl)amino]-3-pyridine-carboxylic acid, ethyl ester

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةat reflux temperature
2. 2
   ترشيحthe amino compound is filtered off

الإجراء التجريبي

22.4 g of 2-chloro-5-cyano-6-methyl-3-pyridine-carboxylic acid, ethyl ester (1 mol) of Example 1(b) are treated in 100 ml of ethanol with 15 g sec. butylamine at reflux temperature with stirring. After the addition of the amine is completed, the solution is poured into 200 ml of cold water, and the amino compound is filtered off. Yield 22 g (84%); m.p. 55°-57° C.

المصدر