تفاعل #560244

معادلة التفاعل

nebivolol

HCl HCl

→

nebivolol hydrochloride

المذيبات

ظروف التفاعل

المعالجة

1. 1
   أخرىIn a preferred embodiment the said form is obtained by conventional spray
2. 2
   أخرىdrying technique
3. 3
   workup.DISSOLUTIONNebivolol hydrochloride is dissolved in alcohol such as methanol
4. 4
   درجة الحرارةunder heating
5. 5
   أخرىto obtain a clear solution
6. 6
   أخرىis then spray dried for a period of 2 to 5 hours

الإجراء التجريبي

In a preferred embodiment the said form is obtained by conventional spray drying technique using a LabPlant SPD-005® spray drier. Nebivolol hydrochloride is dissolved in alcohol such as methanol under heating to obtain a clear solution or adjust pH below 2.0 of nebivolol base solution/suspension in alcohol using aqueous HCl/Alcoholic HCl/HCl gas, which is then spray dried for a period of 2 to 5 hours, and further isolating nebivolol hydrochloride Form T1.

المصدر