تفاعل #55767

معادلة التفاعل

Sulphuryl chloride

ethyl 3-oxopentanoate

→

ethyl 2-chloro-3-oxopentanoate

المذيبات

chloroform

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONaddition the mixture
2. 2
   درجة الحرارةheated
3. 3
   درجة الحرارةunder reflux for 0.5 hour
4. 4
   درجة الحرارةcooled
5. 5
   غسيلAfter washing with water, sodium bicarbonate and water
6. 6
   تجفيفthe solution was dried (sodium sulphate)
7. 7
   تركيزconcentrated

الإجراء التجريبي

Sulphuryl chloride (286 g.) was added dropwise to a solution of ethyl 3-oxopentanoate (300 g.) in chloroform (250 ml.) at 10°-15°. Following addition the mixture was stirred overnight at room temperature, heated under reflux for 0.5 hour and cooled. After washing with water, sodium bicarbonate and water, the solution was dried (sodium sulphate), concentrated, and fractionated to yield ethyl 2-chloro-3-oxopentanoate, b.p. 94°-96°/14 mm.

المصدر