تفاعل #556541

معادلة التفاعل

6-chloropyrimidine-4-carboxylic acid chloride

7-methyl-1,3-dihydro-indol-2-one

aluminium trichloride

→

5-(6-chloro-pyrimidine-4-carbonyl)-7-methyl-1,3-dihydro-indol-2-one

المذيبات

EtOAc

ظروف التفاعل

المعالجة

1. 1
   أخرىThe precipitate formed as black flakes
2. 2
   ترشيحfiltered
3. 3
   أخرىthe phases were separated
4. 4
   استخلاصThe aqueous phase was extracted several times with EtOAc
5. 5
   أخرىThe combined organic phases were dried on sodium sulphate
6. 6
   ترشيحfiltered
7. 7
   أخرىevaporated down i

الإجراء التجريبي

1.92 g (10.9 mmol) 6-chloropyrimidine-4-carboxylic acid chloride, 1.60 g (10.9 mmol) 7-methyl-1,3-dihydro-indol-2-one and 7.33 g (55.0 mmol) aluminium trichloride were heated to 130° C. for 3 h with stirring. The mixture was combined first with ice water and then with EtOAc. The precipitate formed as black flakes was suction filtered and the phases were separated. The aqueous phase was extracted several times with EtOAc. The combined organic phases were dried on sodium sulphate, filtered and evaporated down i. vac.

المصدر