تفاعل #556372

معادلة التفاعل

hydrazine hydrate

ethyl difluoro(quinolin-6-yl)acetate

hydrazine

→

2,2-difluoro-2-quinolin-6-ylacetohydrazide

المردود 92.1%

المذيبات

2-methyl-2-butanol

2-methyl-2-butanol

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe precipitate was filtered off from the reaction mixture
2. 2
   غسيلwas washed with water
3. 3
   أخرىdried at 50° C

الإجراء التجريبي

To a reactor under inert atmosphere was added 31.05 mL 2-methyl-2-butanol and 12.58 mL (0.259 mol) hydrazine hydrate. Then a solution of 26 g (0.103 mol) ethyl difluoro(quinolin-6-yl)acetate in 125 mL 2-methyl-2-butanol was dosed to the hydrazine solution at room temperature. The precipitate was filtered off from the reaction mixture and was washed with water and dried at 50° C. 22.51 g 2,2-difluoro-2-quinolin-6-ylacetohydrazide was obtained in 90% yield.

المصدر