تفاعل #55621

معادلة التفاعل

4-amino-2,6-dimethoxypyrimidin

2-chlorobenzenesulfonylisocyanate

→

N-[(2,6-dimethoxypyrimidin-4-yl)aminocarbonyl]-2-chlorobenzenesulfonamide

المذيبات

methylene chloride

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةrefluxed an additional 15 minutes
2. 2
   أخرىVolatiles were removed under reduced pressure
3. 3
   أخرىthe solid thereby obtained
4. 4
   غسيلwas washed with a little diethyl ether

الإجراء التجريبي

To a mixture of 1.10 g of 4-amino-2,6-dimethoxypyrimidin in 40 ml methylene chloride at ambient temperature and pressure was added 1.60 g of 2-chlorobenzenesulfonylisocyanate. The reaction was stirred 30 minutes and then refluxed an additional 15 minutes. Volatiles were removed under reduced pressure and the solid thereby obtained was washed with a little diethyl ether; yield 2.30 g, m.p. 193°-196°.

المصدر