تفاعل #5557

معادلة التفاعل

5-[3-(hydroxy)propylthio]imidazo[1,2-a]pyridine

triethylamine

acetic anhydride

→

desired product

المردود 100.0%

5-[3-(acetyloxy)propylthio]imidazo[1,2-a]pyridine

المردود 100.0%

المذيبات

methylene chloride

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGthe mixture was further stirred at room temperature for 7.5 hours
2. 2
   غسيلThe reaction mixture was washed with an aqueous 1N sodium hydroxide solution
3. 3
   أخرىdried
4. 4
   workup.DISTILLATIONAfter the solvent was distilled off
5. 5
   أخرىthe residue was purified by column chromatography [eluent: hexane/acetone (1:1)]

الإجراء التجريبي

To a solution of 5-[3-(hydroxy)propylthio]imidazo[1,2-a]pyridine (2.00 g, 9.60 mmoles) and triethylamine (1.60 ml, 11.5 mmoles) in methylene chloride (50 ml) was added acetic anhydride (1.10 ml, 11.6 mmoles) with stirring at room temperature and the mixture was further stirred at room temperature for 7.5 hours. The reaction mixture was washed with an aqueous 1N sodium hydroxide solution and dried. After the solvent was distilled off, the residue was purified by column chromatography [eluent: hexane/acetone (1:1)] to obtain 2.40 g of the desired product (100%, brown oily product).

المصدر