تفاعل #55533

معادلة التفاعل

sodium borohydride

1-cyanomethyl-1-(2-picolyl)pyrrolidinium benzenesulfonate

3-bromopropionitrile

dicyanoamine

→

2-Methyl 3-(1-N-pyrrolidinyl-3-cyanopropyl)pyridine

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   أخرىto give the product
2. 2
   أخرىPurification

الإجراء التجريبي

1-cyanomethyl-1-(2-picolyl)pyrrolidinium benzenesulfonate (see Preparation II) is rearranged and alkylated with 3-bromopropionitrile as in Example 2. The resulting dicyanoamine is decyanated with sodium borohydride in ethanol to give the product. Purification is effected via the picrate.

المصدر